Coronavirus pathophysiology | Pneumonia caused by coronavirus

Share this & earn $10
Physiology Open
Published at : 25 Dec 2020
3814 views
118
3

Pathophysiology of coronavirus

Most common way for the coronavirus to enter our body is through respiratory tract i.e via mouth or nose. If we are exposed to more dose of the coronvirus virus or in case our immune system is not strong , the coronavirus manages to reach to the alveoli. Further outcome depends on how effectively our immune system fights against corona virus.

Role of macrophages
Once the virus is in alveoli, macrophages ingest the virus. Macrophages present the antigen to Helper T cells. Also they release certain chemical known as IL-1 and TNF alpha.

The chemicals IL-1 and TNF alpha, increase the permeability of blood vessels causing fluid to leak out of the vessels. Also, along with that neutrophils, T cells start migrating to outside the blood vessel to help the macrophages leading to development of pneumonia.

In the meantime, some virion particles enter into cells and start multiplying. .
Whenever the cells are infected with virion, the immune system starts various mechanisms:
1. Helper T cells and infected cells produce interferons. These interferons act on the infected cell itself as well as on nearby cells via JAK-STAT pathway. In infected cells, they inhibit viral replication. On nearby cells, they make them resistant to infection by virus.

2. Helper T cells activate cytotoxic T cells which can kill the virus infected cells.

But coronavirus has a mechanism to evade this immune attack.

1. Coronavirus multiply within Double Membrane Vesicles (DMVs) so the cells are not able to identify that they are infected with the virus and thus are unable to produce interferons.
2. The interferons released by T cells also cannot act because the virus blocks the activation of this interferon system by blocking the JAK-STAT pathway.

So the virus keeps on multiplying and hence increasing the virus load tremendously.

As virus multiplies, it releases more and more viruses , infecting more and more cells, confusing more and more macrophages which end up activating immune system in an uncontrolled manner and hence releasing these and many other chemicals which keep on exaggerating the pneumonia.

Because of this diffusion of oxygen is affected causing hypoxemia.

So that’s how people infected with coronavirus succumb to the infection.


#coronavirus
#covid-19
#physiologyopen
pathophysiology of coronaviruscovid19 pathogensiscoronavirus pathogenesis

Creedence Clearwater Revival - Lookin' Out My Back Door (Official Video)

Creedence Clearwater Revival - Lookin' Out My Back Door (Official Video)

The Hoosiers - Worried About Ray (Official Video)

The Hoosiers - Worried About Ray (Official Video)

Safari Animals Figurines and Fun Rescue Adventure Playset

Safari Animals Figurines and Fun Rescue Adventure Playset

Chris Bandi - Would Have Loved Her (Lyrics)

Chris Bandi - Would Have Loved Her (Lyrics)

The Weeknd - Heartless (Official Video)

The Weeknd - Heartless (Official Video)

ROAR! Dinosaurs! | Caitie's Classroom

ROAR! Dinosaurs! | Caitie's Classroom

Роберт Багратян - Всё ещё люблю тебя / Обратный отсчёт - Голос дети 26 апреля 2019 года

Роберт Багратян - Всё ещё люблю тебя / Обратный отсчёт - Голос дети 26 апреля 2019 года

Secrets: Which foods to Avoid during PMS(Period Pain and Cramps) !!

Secrets: Which foods to Avoid during PMS(Period Pain and Cramps) !!

The Chainsmokers - Closer ft. Halsey (Live from the 2016 MTV VMAs)

The Chainsmokers - Closer ft. Halsey (Live from the 2016 MTV VMAs)

The Kealohas: a brief overview of what led up to this point

The Kealohas: a brief overview of what led up to this point

15 Habits of RICH & Successful People

15 Habits of RICH & Successful People

DO NOT CALL SIREN HEAD FROM MINECRAFT AT 3AM!!!

DO NOT CALL SIREN HEAD FROM MINECRAFT AT 3AM!!!

Oftentimes

Oftentimes

Why do we dream? - Amy Adkins

Why do we dream? - Amy Adkins

9 Ways to SNEAK SNACKS into a PLANE! Ways To Sneak FOOD & Simple DIY Ideas by Mr Degree

9 Ways to SNEAK SNACKS into a PLANE! Ways To Sneak FOOD & Simple DIY Ideas by Mr Degree

Crunchy Black Says There Aren't Many People in the Game Like Him and Boosie (Part 3)

Crunchy Black Says There Aren't Many People in the Game Like Him and Boosie (Part 3)

Learn Family Relations Names & English words for family members | Family Members for Kids

Learn Family Relations Names & English words for family members | Family Members for Kids

Dr W. Clay Jackson on the Prevalence of Clinician Burnout

Dr W. Clay Jackson on the Prevalence of Clinician Burnout

Ferreting with some friends and a variety of diffrent dogs

Ferreting with some friends and a variety of diffrent dogs

Microsoft to demonstrate 'Surface' prototypes-snowboard

Microsoft to demonstrate 'Surface' prototypes-snowboard

AMONG US with SUNNY KHAN DURRANI and many others!

AMONG US with SUNNY KHAN DURRANI and many others!

Howard Jones & Nik Kershaw 'Wouldn't It Be Good' - LIVE in 2008

Howard Jones & Nik Kershaw 'Wouldn't It Be Good' - LIVE in 2008

My Foot Is Attached To My Knee | BORN DIFFERENT

My Foot Is Attached To My Knee | BORN DIFFERENT

Eureka Wall w/ Hazel and Alex

Eureka Wall w/ Hazel and Alex

I Want a New Duck

I Want a New Duck

кис-кис - весна (cover by TURN UP!)

кис-кис - весна (cover by TURN UP!)

SWERTE SA BAGONG UPDATE! NEW MONTHLY OFFERS! (ROS UPDATE)

SWERTE SA BAGONG UPDATE! NEW MONTHLY OFFERS! (ROS UPDATE)

Effective brooding techniques in the tropic

Effective brooding techniques in the tropic

Detection of a 2nd Type of Nuclear Fusion Inside the Sun

Detection of a 2nd Type of Nuclear Fusion Inside the Sun

Sophocle : Marque Ton Époque | Citations

Sophocle : Marque Ton Époque | Citations

Dolly Style - Bye Bye Bby Boo

Dolly Style - Bye Bye Bby Boo

BRONNY JAMES Got HUGE! GIANT Growth Spurt! LeBron James Workout Work ETHIC is UNMATCHED

BRONNY JAMES Got HUGE! GIANT Growth Spurt! LeBron James Workout Work ETHIC is UNMATCHED

What's better...being 5'6 or 7ft?

What's better...being 5'6 or 7ft?

WALL STREET RECKONING COMING - FINANCIAL BUBBLES WILL BUST - REALITY COMING TO FINANCIAL MARKETS

WALL STREET RECKONING COMING - FINANCIAL BUBBLES WILL BUST - REALITY COMING TO FINANCIAL MARKETS

Becoming aware of Awareness. Realizing ourselves as Awareness.

Becoming aware of Awareness. Realizing ourselves as Awareness.

Nutiva Organic, Neutral Tasting, Steam Refined Coconut Oil from non-GMO, Sustainably Farmed Coc...

Nutiva Organic, Neutral Tasting, Steam Refined Coconut Oil from non-GMO, Sustainably Farmed Coc...

THE VENTURES - 45th Anniversary Live [8/9]

THE VENTURES - 45th Anniversary Live [8/9]

Building Insane Headlights!

Building Insane Headlights!

UK Ambassador investigated for 'leaking' US secrets in affair with journalist

UK Ambassador investigated for 'leaking' US secrets in affair with journalist

Neil deGrasse Tyson: Trump's Space Force Is Not A Crazy Idea

Neil deGrasse Tyson: Trump's Space Force Is Not A Crazy Idea

British scientists to infect volunteers with coronavirus | Connect the Dots

British scientists to infect volunteers with coronavirus | Connect the Dots

Adding an additional Domain Controller to an existing domain in Windows Server 2012 R2

Adding an additional Domain Controller to an existing domain in Windows Server 2012 R2

SURPRISING MY FUTURE WIFE WITH A NEW CAR! (She Cried)

SURPRISING MY FUTURE WIFE WITH A NEW CAR! (She Cried)

Hydrocarbon Power!: Crash Course Chemistry #40

Hydrocarbon Power!: Crash Course Chemistry #40

20181228116 Children Of Soldiers Bring Airport Terminal To Standstill

20181228116 Children Of Soldiers Bring Airport Terminal To Standstill

Trade Update! ⚖️ Scamming prevention & more trading slots! 👩🏿‍⚖️ Adopt Me! on Roblox

Trade Update! ⚖️ Scamming prevention & more trading slots! 👩🏿‍⚖️ Adopt Me! on Roblox

Why hello boys! Feeling a bit hot under the collar are we? | Britain's Got More Talent 2015

Why hello boys! Feeling a bit hot under the collar are we? | Britain's Got More Talent 2015

The 4 Most Misunderstood Personality Disorders & How to Spot Them

The 4 Most Misunderstood Personality Disorders & How to Spot Them

Describe an area of science that interest you sample answer

Describe an area of science that interest you sample answer